A Patient with Combined CADASIL and MTHFR Homozygosity

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is an inherited disorder caused omni logic plus by a mutation in the NOTCH 3 gene, characterized by early onset of subcortical lacunar infarcts in the absence of vascular risk factors and cerebral microbleeds.Homozygosity for the factor Methylenetet

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Assessment of the potential role of muscle spindle mechanoreceptor afferents in chronic muscle pain in the rat masseter muscle.

BACKGROUND: The phenotype of large diameter sensory afferent neurons changes in several models of neuropathic pain.We asked if similar changes also occur in "functional" pain syndromes.METHODOLOGY/PRINCIPAL FINDINGS: Acidic saline (AS, pH 4.0) injections into the masseter muscle were used to induce persistent myalgia.Controls received saline at pH

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