Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is an inherited disorder caused omni logic plus by a mutation in the NOTCH 3 gene, characterized by early onset of subcortical lacunar infarcts in the absence of vascular risk factors and cerebral microbleeds.Homozygosity for the factor Methylenetet
In search of Nubian master-builders: an architectural drawing from the Cathedral in Faras.
A makeshift drawing from the Cathedral in Faras may be omni logic plus a depiction of the ground plan of a church.Nevertheless, the naive appearance of the sketch and an almost complete lack of sufficient parallels from either Nubia or the Eastern Mediterranean make a proper examination of this caruso rhodiola assumption unfeasible.A reassessment o
Assessment of the potential role of muscle spindle mechanoreceptor afferents in chronic muscle pain in the rat masseter muscle.
BACKGROUND: The phenotype of large diameter sensory afferent neurons changes in several models of neuropathic pain.We asked if similar changes also occur in "functional" pain syndromes.METHODOLOGY/PRINCIPAL FINDINGS: Acidic saline (AS, pH 4.0) injections into the masseter muscle were used to induce persistent myalgia.Controls received saline at pH
SMOOVS: Towards calibration-free text entry by gaze using smooth pursuit movements
Gaze-based text spellers have proved useful for people with severe motor diseases, but lack acceptance in general human-computer interaction.In order to use gaze spellers for public displays, they need to be robust and provide an intuitive interaction concept.However, traditional dwell- and blink-based systems need accurate calibration which contra
TLR7/TLR8 activation and susceptibility genes synergize to breach gut barrier in a mouse model of lupus
BackgroundMounting evidence suggests that increased gut permeability, or leaky gut, and the resulting translocation of pathobionts or their metabolites contributes to the pathogenesis of Systemic Lupus Erythematosus.However, the mechanisms underlying the induction of gut leakage remain unclear.In this study, we examined the effect of a treatment wi